Abstract: Objective To investigate the effect of breast-conserving surgery with modified radical mastectomy on the quality of life of early-stage breast cancer patients. Methods From January 2013 to January 2015， a retrospective analysis of early-stage breast cancer patients（276 cases） in our hospital， including 138 cases of breastconserving surgery group， 138 cases of modified radical mastectomy group. The patients satisfaction， selfrating depression scale （SDS） and selfrating anxiety scale （SAS） were used to evaluate the impact of the quality of life for breast cancer patients in two groups. Rosenberg selfesteem scale （SES）， family cohesion adaptability scale， quality of life measurement table （FA CT-B） were used to perform the questionnaire analysis. ResultsThe SAS and SDS scores of breastconserving surgery group was lower than those of the modified radical mastectomy group with significant statistical difference （P＜0.05）. The patients satisfaction in the breastconserving surgery group was higher than that in the radical mastectomy group， and the difference was statistically significant （P＜0.05）. The measurement results of SES， FA CT-B in the breastconserving surgery group was improved compared with the modified radical mastectomy group（P＜0.05）. Family cohesion and adaptability in the breastconserving surgery group were better than those in the modified radical mastectomy group， and the difference was statistically significant （P＜0.05）. Conclusion The implementation of breastconserving surgery care can improve the quality of life in patients with early-stage breast cancer， relieve patients' psychological and physical discomfort， and promote the rehabilitation of patients.