临床肿瘤学杂志

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肿瘤浸润淋巴细胞在三阴性乳腺癌中作用的研究进展

方和慧,杨芳,管晓翔   

  1. 南京大学医学院临床学院 南京军区南京总医院肿瘤内科
  • 收稿日期:2016-01-22 修回日期:2016-03-29 出版日期:2016-07-30 发布日期:2016-07-30
  • 通讯作者: 管晓翔

Research progress of tumor-infiltrating lymphocytes in triplenegative breast cancer

FANG Hehui, YANG Fang, GUAN Xiaoxiang.   

  1. Department of Medical Oncology, Clinical Medical School of Nanjing University, Nanjing General Hospital of Nanjing Military Command, PLA
  • Received:2016-01-22 Revised:2016-03-29 Online:2016-07-30 Published:2016-07-30
  • Contact: GUAN Xiaoxiang

摘要: 三阴性乳腺癌(TNBC)是一种高度异质性的疾病。因缺乏有效的治疗靶标,故临床预后较差。尽管大量文献报道肿瘤浸润淋巴细胞与TNBC预后之间的关系,但区分不同类型的T淋巴细胞极其重要,因为他们在肿瘤微环境中发挥着不同的作用。此外,有研究发现肿瘤相关巨噬细胞与TNBC预后不良相关。本文将对不同淋巴细胞浸润在TNBC临床预后中的作用作一综述。

Abstract: Triplenegative breast cancer(TNBC) is a heterogeneous disease. It is often characterized by the lack of specific therapeutic molecular targets and poor prognosis. There are increasing evidences about the relationship between tumorinfiltrating lymphocytes and the prognosis of TNBC. However, the distinction between different types of T lymphocytes is extremely important, because of their different roles in the tumor microenvironment. Moreover, tumor-associated macrophages have been associated with a relatively poor outcome in TNBC. In this article, we review the role of different lymphocyte infiltration in the clinical outcome of TNBC.

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