Abstract: Objective To investigate the survival and its related factors of the patients with pathological stage pT2-3N0-1M0 thoracic esophageal squamous cell carcinoma after resection. Methods From January 2011 to March 2014 in the Second Affiliated Hospital of Nanjing Medical University， 127 patients with pathological stage pT2-3N0-1M0 thoracic esophageal squamous cell carcinoma after resection were enrolled. KaplanMeier analysis and Cox multivariate regression analysis were used to evaluate the postoperative survival and its related factors. Nomogram model was applied to implement for 1， 3， 5year survival rate of individual patients.
ResultsUntil the end of followup， the 1， 3， 5year survival rates and median overall survival （OS） were 81.8％， 54.3％， 38.4％ and 40.0 months（95％CI：32.285-47.715）， respectively. Cox multivariate analysis revealed that stage pT（pT2 and pT3）， pN（pN0 and pN1）， intravascular cancer embolus and tumor diameter（≤3 cm and＞3 cm）were the independent factors for OS， risk ratios of pT3， pN1， intravascular cancer embolus and tumor diameter＞3 cm were 2.207， 2.157， 1.758 and 1.607（P＜0.05）. Nomogram model could accurately predict the survival rate of pathological stage pT2-3N0-1M0 thoracic esophageal squamous cell carcinoma. Conclusion The survival of thoracic esophageal squamous cell carcinoma patients with stage pT2-3N0-1M0 after radical treatment shows significantly poor prognosis， the long-term survival of which is closely related to the depth of infiltration， lymph node metastasis， intravascular cancer embolus and tumor diameter， which is worthy of further study.