Abstract: Objective To investigate the association between single nucleotide polymorphisms （SNPs） of long noncoding RNA H19 and susceptibility to prostate cancer. Methods Peripheral venous blood samples were collected from 145 patients with prostate cancer following pathological diagnosis and 162 healthy controls from January 2013 to September 2016 in our hospital. According to the principle of minimum allele frequency＞0.05 and linkage disequilibrium parameter r2＞0.8， four TagSNPs （rs2839698， rs3024270， rs217727 and rs2735971） of H19 were screened. Genotyping was carried out by using TaqMan MGB allele typing kit. The genotype and allele distribution differences and HardyWeinberg balance of two groups in terms of TagSNPs were analyzed. The odds ratio （OR） and its 95％ confidence interval （95％CI） were used to estimate the relative risk of prostate cancer. Results Four TagSNPs of H19 in 145 cases of prostate cancer and 162 cases of healthy people were in Hardy-Weinberg equilibrium state. There was no significant difference in the distribution of rs3024270 and rs217727 genotypes and alleles between the prostate cancer group and the control group （P＞0.05）. As for the distribution of rs2839698， the frequencies of AA genotype and A allele were 28.3％ （41／145） and 47.6％ （138／290） in prostate cancer group， higher than 14.2％ （23／162） and 36.1％ （117／324） in the control group （P＜0.05）. As for the distribution of rs2735971， the frequencies of CC genotype and C allele were 35.2％ （51／145） and 54.1％ （157／290）， higher than 19.7％ （32／162） and 386％ （125／324） in the control group （P＜0.05）. Both rs3024270 and rs217727 have nothing to do with prostate cancer susceptibility. Compared with rs2839698 GG genotype， AA genotype increased risk of prostate cancer to 2.525 folds， while A allele increased to 1.606 folds compared with G allele. Compared with rs2735971 TT genotype， CC and TC+CC genotype increased risk of prostate cancer to 2.820 and 2.017 folds， respectively （P＜0.05）. For rs2735971， C allele increased risk of prostate cancer to 1.879 folds compared with T allele （P＜0.05）. Conclusion H19 rs2839698 and rs2735971 are associated with susceptibility to prostate cancer， and the risk of prostate cancer in individuals with mutant alleles is elevated， which is valuable for screening prostate cancer susceptible populations.