Abstract: Objective To investigate the differences of clinicopathologic characteristics and prognoses of gastric cancer between patients with or without family history of gastric cancer. Methods A retrospective study was conducted in 456 gastric cancer patients from 2011 to 2015， and among them 102 cases were with family history of gastric cancer. A two-sided χ2 was used to test the difference of clinicopathologic characteristics between patients with or without family history of gastric cancer. Survival curves were calculated by Kaplan-Meier method with Log-rank test. Both univariate and multivariate Cox regression models were used to analyze risk factors that impact overall survival （OS）. Results In patients with family history of gastric cancer， the proportions of patients with onset age ≥50 years， the longest diameter of tumor ＜5 cm， histological grade of Ⅰ-Ⅱ and M0 stage were significantly higher than that in patients without family history of gastric cancer （P＜0.05）. The median OS of patients with family history of gastric cancer was 56.1 months， longer than 51.0 months of those without family history of gastric cancer， but without statistic significance （P=0.318）. However， in the subgroup of onset age ≥50 years， patients with family history of gastric cancer had OS superiority than those without family history of gastric cancer （unachieved vs. 53.0 months， P=0.021）. Furthermore， Cox regression models analysis showed that N stage and M stage were independent factors influencing OS in patients with family history of gastric cancer， and the longest diameter of tumor， tumors location and M stage were independent factors influencing OS in those without family history of gastric cancer. Conclusion Gastric cancer patients with or without family history of gastric cancer have different clinicopathologic characteristics， and OS between those patients may have certain difference.