Abstract: Objective To investigate the clinical and pathological features of gyriform schwannoma（GSW）. Methods The clinical features， performance of light microscopy， immunohistochemistry and ultrastructure of 4 cases of GSW were observed. Results There were two males and two females. Each of the 2 cases was located in the head and neck. GSW was a slowly growing painless mass or slight tenderness with clear boundary. The capsule of the tumor was integrity， with diameter of 2-4 cm， and the section was grayish yellow. The tumor tissues distributed as solid flakes， were composed of round or oval cells. The cytoplasm was rich and red， and the nuclei were arranged closely. Tumor cells were matched with each other in irregularly trabecular or branched manner. Protuberances with obvious polarity were distributed in trabecular or branched nuclei on both sides， forming gyriform appearance. Immunohistochemical method showed that there were expressions of Vimentin， S-100 protein， CD56， Bcl-2 and PGP9.5，with diffuse weakly-positive expression of CD99，and no expression of calponin， β-catenin， desmin， CD34， MSA， SMA， GFAP， collagen IV， CyclinD1， laminin， AE1／AE3 and p63. The electron microscopy observation showed that tumor cells possessed features of nerve sheath cells. Conclusion GSW has unique morphologic features and its immunophenotype and ultrastructural characteristics both possess characteristics of nerve sheath cell differentiation. Therefore， it is presumed that GSW is a new subtype of schwannoma.