Abstract:

Objective To investigate the expression and clinical significance of long noncoding RNA（LncRNA） RAB11B-AS1 in gastric cancer. Methods The expression of LncRNA RAB11B-AS1 was detected by realtime quantitative PCR（QRT-PCR） in 83 cases of gastric cancer tissues and normal gastric tissues. The relationship of LncRNA RAB11B-AS1 expression with the clinicopathological features and prognosis of the patients was analyzed.
ResultsThe expression of LncRNA RAB11B-AS1 in gastric carcinoma tissue was 6.954±1.080， higher than 1.061±0.090 in normal gastric tissue， and the difference was statistically significant （P＜0.05）. The expression of LncRNARAB11B-AS1 was not related to sex， age and tumor location（P＞0.05）， but related to clinical stage， lymph node metastasis， distant metastasis， tumor differentiation and survival status （P＜0.05）. The median progression free survival （PFS） and overall survival （OS） of patients with high expression of LncRNA RAB11B-AS1 was 19.0 months and 29.0 months respectively， which was lower than 32.0 month and 430 months of patients with low expression of LncRNA RAB11B-AS1 （P＜0.05）. Cox multivariate regression analysis suggested that LncRNA RAB11B-AS1 expression， distant metastasis and clinical stage were independent prognostic factors of gastric cancer （P＜0.05）. Conclusion LncRNA RAB11BAS1 is involved in the regulation of gastric cancer， and can be used as a potential molecular marker for the diagnosis and prognosis of gastric cancer.