Abstract: Objective To explore the expression and clinical significance of Ecadherin and β-catenin in osteosarcoma tissues. Methods From April 2012 to October 2015， 54 specimens of osteosarcoma tissues and 22 specimens of osteochondroma tissues were enrolled. Immunohistochemistry was used to detect the expression of Ecadherin and βcatenin in those above tissues. The correlation of the expression of E-cadherin， β-catenin and clinical parameters of osteosarcoma were analyzed. Results In 54 specimens of osteosarcoma tissues， the positive rate of E-cadherin protein was 35.2％（19／54）， significantly lower than 68.2％（15／22） in osteochondroma tissues （P＜0.05）. However the positive rate of β-catenin protein was 68.5％（37／54）， significantly higher than 9.1％（2／22） in osteochondroma tissues （P＜0.05）. The expression of Ecadherin protein was associated with Enneking stage and metastasis （P＜0.05）. The expression of β-catenin protein was associated with tumor size， Enneking stage and metastasis （P＜0.05）. Moreover， the expression of Ecadherin and β-catenin was negatively correlated （r=-0.764，P＜0.05）.
ConclusionE-cadherin and βcatenin are abnormally expressed in osteosarcoma tissues， and they are correlated to Enneking stage and metastasis. Both of them play a role in the development and progression of osteosarcoma.