重编程相关的长链非编码RNA与肿瘤的研究进展

临床肿瘤学杂志 ›› 2018, Vol. 23 ›› Issue (8): 752-756.

重编程相关的长链非编码RNA与肿瘤的研究进展

南京东南大学附属中大医院肿瘤科

出版日期:2018-08-31 发布日期:2018-09-07

Research progression of regulator of reprogramming long noncoding RNA in tumors

Department of Oncology， Zhongda Hospital Affiliated to Southeast University

Online:2018-08-31 Published:2018-09-07

摘要/Abstract

摘要： 人类基因组中存在大量长链非编码RNA（lincRNA），其在多种水平调控基因的表达且与多种疾病发生发展密切相关。重编程相关的长链非编码RNA（lincRNA ROR）是新近发现的对细胞重编程有重要调控作用的lincRNA，在多能干细胞形成、DNA损伤、氧化应激等过程中起重要作用。LincRNA ROR在多种肿瘤细胞中异常表达并在其发生、发展及治疗等过程中发挥作用。本文主要就lincRNA ROR在多种肿瘤中的表达及其对肿瘤发生发展中的作用机制作一综述。

Abstract: In the human genome，there are a large number of long noncoding RNAs（lincRNAs）， and they regulate gene expression at various levels and are closely related to the development of many disease. Regulator of reprogramming long noncoding RNA（lincRNA ROR）is a newly discovered lincRNA which plays an important role in the formation of pluripotent stem cells， DNA damage， oxidative stress etc. A number of studies have shown that lincRNA ROR plays an important role in the occurence， development and treatment of tumor. This paper reviews the expression of lincRNA ROR in various tumors and the mechanism of its action in the development of tumor.

Key words: Tumor, Regulator of reprogramming long noncoding RNA （lincRNA ROR）, Biological function

封逍遥, 苏翔宇, 刘琳. 重编程相关的长链非编码RNA与肿瘤的研究进展[J]. 临床肿瘤学杂志, 2018, 23(8): 752-756.

FENG Xiaoyao, SU Xiangyu, LIU Lin. . Research progression of regulator of reprogramming long noncoding RNA in tumors[J]. Chinese Clinical Oncology, 2018, 23(8): 752-756.

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