Abstract: Objective To investigate the expressions of the hypoxia induced factor 1（HIF-1α）and the major histocompability complex class Ⅰ chain-related molecule（MIC A／B） in pancreatic carcinoma，and to detect their clinico-pathologic characteristics and the correlation of them. Methods The expressions of HIF-1α and MIC A／B were tested by immunohistochemical method in 42 pancreatic carcinoma，9 chronic pancreatitis and 8 normal pancreas tissues. Then we analyzed the correlation between HIF-1α and MIC A／B as well as the relationship with the clinical pathological factors. Results IHC showed that the positive rate of HIF-1α and MIC A／B in pancreatic carcinoma tissue were 76.2％ and 90.5％，higher than chronic pancreatitis tissue （22.2％，22.2％）or normal pancreatic tissue（0，12.5％）.The positive rates of HIF-1α and MIC A/B in samples of Ⅰ-Ⅱ stage were less than those in samples of Ⅲ-Ⅳ stage. The positive rate of HIF-1α in pancreatic carcinoma with lymphnode metastasis was 91.3％，higher than that in samples without lymphnode metastasis. In samples of different pathology and clinical stages，the expression level of MIC A／B was significant different（P＜0.05）.There was inverse correlation between MIC A／B and HIF-1α（r=.0.522，P＜0.001）. Conclusion The MIC A／B may be down-regulated by HIF-1αin pancreatic carcinoma and it may be one of the mechanism that immune escape is induced by hypoxia in carcinoma.How to improve the hypoxia microenvironment will give us a new idea to treat pancreatic carcionoma by immune therapy.