乳腺癌化疗相关认知障碍的前瞻性记忆损害的特征

临床肿瘤学杂志

乳腺癌化疗相关认知障碍的前瞻性记忆损害的特征

程怀东¹，陈婵娟¹，杨震¹，张明军¹，陈振东¹，汪凯¹

1 230601合肥安徽医科大学第二附属医院肿瘤科 2 230022安徽医科大学第一附属医院神经心理学实验室

收稿日期:2012-06-14 修回日期:2012-08-31 出版日期:2012-11-30 发布日期:2012-11-30
通讯作者: 陈振东

CHENG Huai-dong， CHEN Chan-juan， YANG Zhen， ZHANG Ming-jun， CHEN Zhen-dong， WANG Kai

Department of Oncology，the Second Affiliated Hospital of Anhui Medical University， Hefei 230601， China

Received:2012-06-14 Revised:2012-08-31 Online:2012-11-30 Published:2012-11-30
Contact: CHEN Zhen-dong

摘要/Abstract

摘要： 目的探讨乳腺癌患者出现化疗相关认知障碍（CICI）中基于事件的前瞻性记忆（EBPM）和基于时间的前瞻性记忆（TBPM）损害的特征。方法分别建立EBPM和TBPM的神经心理学测验方法，选取27例乳腺癌术后辅助化疗患者（观察组）以及年龄、教育程度相匹配的30例健康者（对照组）进行测试，记录两组数据并比较。结果观察组的EBPM得分为1.11±1.09，明显低于对照组的2.23±0.77（P＜0.01）；观察组和对照组的TBPM得分分别为4.33±1.24和4.83±1.09，差异无统计学意义（P＞0.05）。结论乳腺癌患者出现CICI中存在前瞻性记忆损害，主要表现为EBPM损害，而TBPM损害不明显。

Abstract:

Objective To investigate the eventbased prospective memory （EBPM） and timebased prospective memory （TBPM） disorders associated with chemotherapyinduced cognitive impairment in patients with breast cancer. Methods Twentyseven cases with breast cancer who underwent adjuvantchemotherapy after operation，and 30 healthy women with matched age and education level were administered with a neuropsychological battery of tests including EBPM and TBPM tasks. Results The EBPM score of breast cancer patients and healthy controls were 1.11±1.09 and 2.23±0.77， with significant differences（P＜0.001）.The TBPM score of breast cancer patients and healthy controls were 4.33±1.24 and 483±1.09（P＞0.05）. Conclusion Breast cancer patients who undergo adjuvant chemotherapy show deficits in EBPM， but not in TBPM.

程怀东¹，陈婵娟¹，杨震¹，张明军¹，陈振东¹，汪凯¹. 乳腺癌化疗相关认知障碍的前瞻性记忆损害的特征[J]. 临床肿瘤学杂志, 2012, 17(11): 980-.

CHENG Huai-dong， CHEN Chan-juan， YANG Zhen， ZHANG Ming-jun， CHEN Zhen-dong， WANG Kai

. [J]. Chinese Clinical Oncology, 2012, 17(11): 980-.

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