Abstract: ObjectiveTo investigate the efficacy and safety of interventional treatment for locally advanced cervical cancer.
Methods There were 122 cases of advanced cervical cancer patients diagnosed by pathology. All the patients were treated by the feeding artery embolism together with either uterine artery chemoembolization or internal iliac-arterial infusion chemotherapy. Chemotherapy was based on cisplatin-based combination regimens. The gelfoam particle containing mitomycin or epirubicin was employed as embolic agent. The change of tumor size was observed and clinical data were evaluated 2 weeks after the operation of intervention. Results The clinical remission was 100.0％. Twenty-two cases achieved CR，66 cases achieved PR，28 cases achieved SD and 6 cases achieved PD. The reponse rate was 72.1％. Among the 122 patients, the interventional treatment was carried out one time in 29, two times in 42, three times in 35 and four times in 16. Ninety-eight cases underwent successful surgical resection. The main adverse reactions after interventional procedure included fever,digestive reaction,lellkocytopenia and abdominal pain, and these could be controlled by symptomatic treatment. Eighty-six patients were followed-up，the survival rates of 3- and 5-year were 81.4％ and 68.6％，respectively. Conclusion Interventional treatment for locally advanced cervical cancer is safe and effective. It reduces the tumor size，decreases tumor staging，and improves the resection rates.