Abstract: Objective To evaluate the efficacy and safety of continuous intrathecal morphine infusion therapy in patients with moderate to severe abdominal visceral cancer pain. Methods Thirty-two patients with moderate to severe abdominal visceral cancer pain were implanted with intrathecal catheter and connected with continuous external electronic PCA pump to implement intrathecal morphine analgesia， and the VAS score and the QLQC30 quality of life score before and after analgesic application were recorded. Adverse reactions were observed. Results After the application of continuous intrathecal morphine analgesia with 1 week dose adjust，the VAS pain score was 3.12±1.12，lower than 8.01±0.81 before the application（P＜0.05），and the QLQ-C30 quality of life score was 45.52±3.34，higher than 29.45±2.50 before application（P＜0.05）. No respiratory depression and intrathecal inflammation occurred in all patients；the adverse effects included pruritus，constipation，headache and urinary retention. Conclusion The effect of continuous intrathecal morphine infusion is effective，with low incidence of adverse reactions，low-cost and convenient operation，providing satisfied treatment for patients with moderate to severe cancer pain.