Abstract: Genes that inhibit metastasis without affecting primary tumor formation at the primary site are known as metastasis suppressor gene. Breast cancer metastasis suppressor 1（BRMS1） was identified as a new metastasis suppressor gene in 2000. Documented studies have confirmed that BRMS1 is a potent metastasis suppressor in many types of tumor not limited to breast cancer. In this review， we provide an overview of its biology function， the relationships with tumor metastasis， action mechanism and clinical significance.