Abstract: Objective To evaluate the efficacy and side effect of hepatic transcatheter arterial infusion（TAI）and chemoembolization（TACE） in the treatment of liver metastases of neuroendocrine tumors（NET）. Methods Forty-eight patients with liver metastases of NET underwent interventional therapy from August 2002 to September 2009. Thirty patients with rich blood supply and middling blood supply underwent TACE，while 18 patients with poor blood supply underwent TAI. The efficacy was evaluated 1 month after the interventional therapy. Results Interventional therapy was successfully completed in 48 patients. Patients underwent TACE finished 4.5 times（range 2-9 times） and those underwent TAI finished 4.1 times（range 1-10 times）. The main symptoms and signs in all patients were relieved at different extent with 5 cases in CR，27 in PR，10 in SD and 6 in PD, and the effective rate was 66.6%. The median time to progression（TTP）was 10.0 months and the median overall survival（OS）was 28.0 months in 48 patients. In TACE group，the median TTP was 9.5 months，and median OS was 270 months，while in TAI group were 8.5 months and 24.0 months. The main side effects were pain，fever，vomiting／nausea，fatigue and leukopenia，mainly in grade 1-2. Conclusion Interventional therapy selecting proper modality based on the metastatic lesion's blood supply patterns for unresectable liver metastases of NET may obtain satisfactory efficacy.