Abstract: Signal transduction is a process causing changes of gene expression in cells by signals through the cell membrane or intracellular messenger molecule. Therefore， cell signal transduction disorder or abnormality， will inevitably lead to cell growth， differentiation， metabolism and biological abnormalities， resulting in various diseases and even cancer. The cell signal transduction pathways associated with lung cancer include Wnt， Notch， tyrosine kinase and Hedgehog signal transduction pathway. This article makes a review on recent research.