Abstract: Alpha fetoprotein（AFP）producing gastric cancer is featured with high malignancy， rapid progress， easy to transfer， poor prognosis and etc， drawing more attention than ever before. It is considered to be a special type of gastric cancer. Currently， treatment of AFP-positive gastric cancer follows AFP-negative gastric cancer， but the effect is not as good as the common AFP-negative gastric cancer. Therefore， it is very important to explore clinicopathological features of AFP-producing gastric cancer， especially molecular biological characteristics on the diagnosis and individualized treatment. This paper summarized the development of the definition of AFP-producing gastric cancer， clinical characteristics， molecular pathology features， treatment status and other aspects.