Abstract: ObjectiveTo evaluate the efficacy and side effects of sodium glycididazole（CMNa） combined with concurrent radiochemotherapy（CRT） for locally advanced esophageal cancer. Methods From June 2012 to November 2013， 87 patients pathologically confirmed as esophageal cancer were randomized into CMNa+CRT group（n=44） and CRT group（n=43）. Radiotherapy was given by 6 MV Xray on conventional schedule（20Gy/f， 5 fractions a week， DT 50Gy）. CMNa was given intravenously 800mg/m2， every Monday， Wednesday and Friday 03h before radiation. Chemotherapy regimen contained cisplatin 125mg/m2 iv d1d5， and fluorouracil 450mg/m2 iv d1d5 with 28 days of a cycle for 2 cycles. Results All patients were evaluable. Patients in CMNa+CRT group achieved 31 CR， 8 PR， 4 SD, 1 PD, and responce rate（RR） was 907%；While in CRT group，patients got 25 CR，7 PR， 9 SD, 2 PD, and RR was 744%. There were significant differences between RR of the two groups（P=0043）. Main side effects were grade 12 bone marrow inhibition， hepatic dyfunction, radioactive esophagitis and radioactive pneumonia， with no differences（P＞0.05）.The 1-year survival rates were 900% and 833% in CMNa+CRT group and CRT group with no differences（P＞0.05）.
Conclusion CMNa combined with CRT for locally advanced esophageal cancer can improve healing efficacy obviously and do not cause severe side effects.