Abstract: Objective To investigate the efficacy and safety of CT-guided percutaneous radiofrequency ablation（RFA） in the treatment of specificlocation hepatic carcinoma. Methods From May 2008 to April 2012， 47 patients with 63 maglignant hepatic lesions which are less than 3cm and close to the large vessels or important extrahepatic organs were treated by CTguided percutaneous radiofrequency ablation. All patients were followed up by clinical and enhancements CT scan respectively in the first month， third month， sixth month， ninth month and twelveth month after RFA. The categorical data such as complete necrosis rate， local tumor progression rate， tumor intrahepatic recurrence rate and survival rate were analyzed. Results All patients were received CTguided percutaneous radiofrequency ablation successfully. The complete necrosis rate of specificlocation hepatic carcinoma was 88.89％（56／63） in one month after RFA. The local tumor progression rate was 4.77％（3／63）， 3.17％（2／63）， 3.17％（2／63） and 1.59％（1／63） respectively in the third， sixth， ninth and twelfth month after RFA. The tumor intrahepatic recurrence rate was 15.87％（10／63）， 4.76％（3／63）， 12.70％（8／63）and 3.17％（2／63） in the third， sixth， ninth and twelfth month after RFA. During the follow-up period， the 1-， 3-， 5-year survival rates of 47 patients were 82.98％（39／47）， 63.83％（30／47） and 36.17％（17／47） after RFA. No severe complications occurred. There were 6 cases complicated with hepatic subcapsular hematoma， 10 cases complicated with postoperative fever which were relieved by symptomatic treatment. Conclusion CT-guided percutaneous radiofrequency ablation for specificlocation hepatic carcinoma was safe and effective.