Abstract: Objective To evaluate the value and safety of argon-helium cryoablation in the treatment of solitary pulmonary nodule（SPN）. Methods The clinical data of 34 patients who diagnosed as SPNs by CT from January 2006 to May 2014 were reviewed. All the patients underwent biopsy and argonhelium cryoablation. CT features was applied to evaluate the clinical efficacy of argon-helium cryoablation treatment. Results All patients were diagnosed as malignant lesions by CT imaging. There were 34 patients diagnosed as 25 lung adenocarcinoma， 6 lung squamous cancer and 3 colon metastatic cancer by biopsy. The 34 patients were successfully completed argonhelium cryoablation treatment. Intraoperative CT view demonstrated that the focal area of ice hockey completely covered 30 cases， and the other 4 cases of ice hockey covering 90％ lesions. There were not intraoperative and postoperative pleural effusion， subcutaneous emphysema and pulmonary infection. Three months after operation， the CT scan displayed that there were CR in 18 patients， PR in 12， NC in 4 patients， and the effective rate was 88.2％. Six months after operation， the CT scan displayed that there were CR in 18 patients， PR in 12 patients， NC in 2， PD in 2 patients， and the effective rate was 88.2％. Twelve months after operation， the CT scan displayed that there were CR in 18 patients， PR in 10 patients， NC in 1 patient， PD in 5 patients， and the total effective rate was 82.3％. There were pneumothorax without symptoms in 2 cases， a small number of haemoptysis in 8 cases， mild chest pain in 5 cases， mild chest tightness in 10 cases， and fever in 6 cases after the operation. The 2-， 5-year survival rate was 61.7％ and 38.2％. Conclusion Argon-helium cryoablation is safe and effective treatment for SPN that can't resected by surgery.