Abstract: Objective To investigate the related factors for prognosis of estrogen receptor（ER）-positive breast cancer. Methods The clinical and pathological data of 229 patients with ER-positive breast cancer from Jan 2006 to Nov 2009 were collected. The onset of age， menstrual status， tumor size， tumor grade， lymph node ratio（LNR）， expression patterns of PR and Her-2， neoadjuvant chemotherapy and radiotherapy were analyzed by Kaplan-Meier survival plots and multivariable Cox hazard regression analysis to identify prognostic factors for survival. Results In this retrospective analysis，15.70％ of 223 patients who had completed the follow-up suffered from local recurrence or metastasis. The Cox regression revealed that the tumor size， LNR， expression patterns of PR and Her-2 affected the recurrence-free survival after the endocrine therapy of breast cancer. Conclusion Large size of tumor， high LNR， over-expression of Her-2 and loss of PR are risk factors for recurrence／metastasis of ER-positive breast cancer.