Abstract: Objective To evaluate the effectiveness of oxycodone combined with opioid receptor antagonists in the management of pain. Methods We searched Pubmed， Embase， Cochrane Library， and CNKI database to acquire the randomized controlled trials （RCTs） about oxycodone combined with opioid receptor antagonists in the treatment of pain. After evaluating methodological quality and extracting data， Metaanalysis was performed using RevMan5.1 software. Results A total of 6 RCTs involving 2003 patients were included. Metaanalysis showed that the combination group was superior to the oxycodone group with significant differences in the bowel function index scores（MD=-13.86， 95％CI：-16.85- -10.86， P＜0.000 01） and the incidence of constipation（RR=0.70， 95％CI：0.61-0.80，P＜0.000 01）. There were no significant difference in the pain intensity scores（MD=0.06， 95％CI：-0.17-0.29，P=0.60）， the incidence of diarrhea（RR=1.22， 95％CI：0.79-1.89， P=0.37）， the incidence of adverse reactions of the nervous system（RR=1.08， 95％CI：0.88-1.32，P=0.48） and general disorders or administration site（RR=1.11， 95％CI：0.81-1.53， P=051）. Conclusion Compared to oxycodone alone group， the combination group promot the bowel function and reduce the incidence of constipation without affecting analgesia situation and can not increase the incidence of adverse reactions， and thus it can be an ideal analgesic method.