Abstract: Invasion and metastasis are the basic characteristic of gastric cancer， and as well as the main cause of death in gastric cancer patients. Epithelial cadherin（E-cadherin） plays an important role in the oncogenesis and development of gastric cancer. The decreased expression of E-cadherin can induce epithelial-mesenchymal transition（EMT）.So it is very significant for the further study on the relationship between E-cadherin and gastric cancer. It may provide a new theoretical basis for the treatment of gastric cancer. In this paper， we review the progression in E-cadherin for the invasion and metastasis of gastric cancer.