Abstract: Objective To evaluate the efficacy and safety of oxycodone hydrochloride controlledrelease tablets in titration of moderate or severe caner pain for background. Methods Eighty-one patients suffering from moderate or severe cancer pain without history of opioid were divided into two groups： Group A（42 cases） used shortacting morphine tablets 10 mg per 4 h to start titration； Group B（39 cases） used oxycodone hydrochloride controlledrelease tablets 10 mg per12 h as background， then patients received titration following NCCN pain’s guide. After 24 h total opioid dose and translation to oxycodone hydrochloride controlledrelease tablets at last were calculated and cumulated. Meanwhile， the efficacy and safety of two groups within 24 hours observation period were compared.
Results The total efficiency was 82.9％ in group A and 87.2％ in group B. Four hours after titrating， pain relieving objective response rate of group A decreased sharply into 58.3％ while group B up to 77.0％ with statistically significant differences（P＜0.05）. Twelve hours after titrating, the pain relieving objective response rates were similar in two groups, and the difference was no statistically significance（P>0.05). The main adverse reactions of two groups were including constipation， nausea and vomiting， dizziness， dry mouth， drowsiness and dysuria， which could be relieved by symptomatic treatment. Conclusion Oxycodone hydrochloride controlledrelease tablets are effective and safty in relieving moderate or severe cancer pain steady in titration as background.