Abstract:

Hepatocellular carcinoma （HCC） is one of the most common malignancy tumors in the world， which is mainly caused by Hepatitis B virus （HBV） infection. HBV DNA integration may promote tumorigenesis via cis-activation of oncogenes or altered tumor suppressor activity, genomic destabilization and production of mutant HBV proteins with tumor-promoting potential. The X gene product of HBV （HBx） has extensive trans-activating functions， which can regulate cell apoptosis， suppress cell DNA repair， intervene intracellular signaling pathways and change epigenetic. In this review， we summarized the research progress of prevalence and incidence of HBV related HCC， HBV DNA integration and HBx protein.