Abstract:

Lung cancer is the leading cause of cancer deaths throughout the world. Non-small cell lung cancer （NSCLC） is the most common type of lung cancer. However， its pathogenesis has not been elucidated. Recently， researches have shown that p44/WDR77 expression is essential for the growth of lung epithelial cells and orthotropic lung adenocarcinoma tumors. The expression of 44-KDa androgen receptor cofactor/WD repeat domain 77 （p44/WDR77） gene in NSCLC is significantly higher than that in adjacent tissues. Loss of p44/WDR77 expression in lung epithelial cells and lung adenocarcinoma cancer cells leads to G1 cell cycle arrest via the p21-Rb-E2F signaling pathway. P44/WDR77 was re-expressed in lung cancer， and silencing p44/WDR77 expression strongly inhibited growth of lung adenocarcinoma tumor xenografts in mice. This article will briefly summarize the research progresses of p44/WDR77 in NSCLC.