Abstract: Objective To detect the special AT rich sequence binding protein（SATB1） expression in Uygur patients with breast cancer，and explore its relationship with clinicopathologic characteristics. Methods One hundred and fiftyeight Uygur patients with breast cancer from Jan. 2014 to Jan. 2015 in Xinjiang Tumor Hospital were enrolled， including 26 cases of carcinoma in situ and 132 cases of invasive carcinoma. SATB1 expression in cancer tissues were detected by immunohistochemistry method, and the relationship between SATB1 expression and clinicopathologic characteristics was analyzed.
Results The positive expression rate of SATB1 in paracarcinoma tissues was 8.0％（4／50）， in carcinoma in situ tissues was 42.3％（11／26）， and in invasive carcinoma tissues was 70.5％（93／132）. The difference was statistically significant （P＜0.05）. In breast invasive carcinoma patients， SATB1 expression was related with primary tumor size， lymph node metastasis, TNM staging and histological grade（P＜0.05）， but not related with the age， menopausal status， pathological types， hormone receptors and HER2 expression （P＞0.05）. Conclusion SATB1 expression in breast cancer tissue of Uygur patients can be influential in the occurence and development of breast cancer.