Abstract: Objective To investigate the prognostic value of E-cadherin and vimentin in early squamous cervical carcinoma and its correlation with clinicopathologic features. Methods Fifty samples of cervical squamous carcinoma from patients who received radical resection were collected. The expressions of E-cadherin and vimentin were detected by immunohistochemistry. The prognostic value of EMT markers and its relationship with clinicopathologic features in early（stage Ⅰb-Ⅱa） cervical cancer was analyzed. Results The high-expressed rate of E-acadherin in cervical cancer was 44.0%, and the positive rate of vimentin was 36.0%. The expression of E-cadherin was closely associated with pathologic differentiation degree and lympho vascular space invasion（LVSI）（P＜0.05）， while vimentin was related to pathologic differentiation degree and lymph node metastasis （P＜0.05）. Univariate survival analysis showed that lymph node metastasis， depth of myometrial invasion and E-cadherin significantly associated with overall survival （P＜0.001， P=0.037， P=0.028）. Patients with positive expression of vimentin demonstrated a trend of unfavorable prognosis， which had a 5-year survival rate of 72.2％ compared with 87.4％ in those patients with negative vimentin expression （P=0.136）. Cox proportional hazards regression showed that lymph node metastasis and E-cadherin were independent prognostic factors of 5-year overall survival （P=0.037， P=0.014）. Conclusion The gain of E-cadherin and the loss of vimentin known as “EMT” play a crucial role in tumor cell invasiveness and metastasis. E-cadherin and lymph node metastasis were independent prognostic factors for 5-year overall survival.