Abstract:

Objective To explore the clinical features， treatment and prognosis of primary pulmonary mucosa-associated lymphoid tissue lymphoma （MALTL）.

Methods From 2012 to 2015， seven primary pulmonary MALTL were treated in Nanjing Drum Tower Hospital. The clinical and follow-up data of seven patients were collected and their clinical features， treatment and prognosis were analyzed. Results Among seven patients of primary pulmonary MALTL， 2 cases were female and 5 cases were male with age between 45-62 years old. Six patients had respiratory symptoms and three of them had B-symptoms，with Ki-67 from 5% to 15% and International Prognostic Index （IPI） from 0 to 2. The PET/CT findings were nodules or consolidated mass with air bronchograms. Five patients received chemotherapy， including COP/CHOP with or without rituximab. The effect was partial remission or stable. Conclusion The symptom of primary pulmonary MALTL patients is nonspecific. PET/CT is useful in staging and evaluation of prognosis. The prognosis is overall good. Individual patient can appear certain invasive. The therapeutic consensus should be established with the clinical features， staging， IPI score and the extent of disease.