Abstract: Objective To evaluate the value of lymphocyte and monocyte ratio（LMR）in predicting the prognosis of epithelial ovarian cancer （EOC）. Methods A total of 189 EOC patients from February 2006 to April 2014 were enrolled in this study. Receiver operating characteristic curve（ROC）was employed to analyze the best diagnostic value of LMR for EOC. The relationship of clinicopathological characteristics with LMR level was analyzed. Cox hazard-ratio model was used to determine factors influencing the prognosis of EOC. Results ROC analysis showed that the cut-off point of LMR was 1.850， and then patients were divided into low LMR group（n=39， LMR≤1.850） and high LMR group （n=150， LMR＞1.850）. LMR level was related to age， CA125， FIGO stage， neutrophil to lymphocyte ratio， platelet to lymphocyte ratio and albumin （P＜0.05）， but not with histological grade，pathological grade，hemoglobin and residual lesions （P＞0.05）. The progressionfree survival of high LMR group and low LMR group was 91 months and 65 months （P＜0.001） and the overall survival of them were 105 months and 67 months （P＜0.001）. Cox hazard-ratio model found that age，CA125， FIGO stage， LMR were the independent factors influencing progression-free survival （P＜0.05）. Age， FIGO stage， LMR were the independent factors influencing overall survival （P＜0.05）. ConclusionLMR is an independent prognosis factor influencing prognosis of EOC，which can be used as a marker to predict the prognosis of EOC.q