Abstract: Objective To investigate the influence of Shenchai keli on the common adverse reactions in chemotherapy of advanced gastrointestinal tumors.
Methods A total of 64 patients diagnosed with advanced gastrointestinal tumors were randomly divided into 2 groups. Thirtytwo cases with Shenchai keli combined chemotherapy was treatment group， 32 cases with simple chemotherapy was control group. Blood routine examination， immune function， quality of life and the changes of the main indicators between two groups before and after chemotherapy were compared after 2 curative cycles. Results Decreasing of white blood cell， neutrophile granulocyte， blood platelet of treatment group were smaller than those of control group （P＜0.05）. The proportion of CD4+T cell，CD4+／CD8+ and NKT cell of treatment group were higher than those of control group （P＜0.05）. The improvement rate of nausea and vomiting， pain， loss of appetite in treatment group were higher than those in control group （P＜0.05）. Conclusion Combined application of Shenchai keli and chemotherapy can significantly improve the common adverse reactions in advanced gastrointestinal tumors.