Abstract: Objective To explore the clinicopathological characteristics and prognosis of angiosarcoma （AS）. Methods In a retrospective analysis， the clinical and followup data of 24 patients with AS treated by the Third Affiliated Hospital of Kunming Medical University from January 1998 to December 2015 were analyzed. Eight cases only received the surgery and other 16 cases received comprehensive treatment， including surgery plus chemotherapy， surgery plus radiotherapy， surgery plus radiotherapy and chemotherapy and surgery plus radiotherapy and immunotherapy. The clinical characteristics and prognosis of AS were analyzed. The factors influencing the prognosis of the patients were analyzed with Cox risk proportional regression model.
Results The medium diseasefree survival of whole group was 12.0 months， including 9 cases （37.5％） of local recurrence and 18 cases （75.0％） of distant metastasis. The medium overall survival of whole group was 24.0 months， and 1， 3， 5 and 10year survival rates were 65.2％， 45.6％， 30.4％ and 13.2％， respectively. Univariate analysis showed that tumor size， stage, grade malignancy and treatment patterns associated with prognosis. Multiple factors analysis showed tumor size， grade malignancy， stage and treatment patterns were independent prognostic factors.
ConclusionThe treatment of AS should adopt comprehensive therapy that based on the radical surgery and supplemented by radiotherapy， chemotherapy and targeted therapy， etc. Prognosis should consider synthetically age， tumor size， malignant degree， stage， treatment and relapse transfer. It is the key to take comprehensive treatment for the first time.