Abstract: Objective To investigate the correlation between metabolic parameters of 18F-FDG PET／CT and clinicopathological features of colorectal cancer（CRC）. Methods The study comprised 84 patients with colorectal cancer. All patients were underwent 18F-FDG PET／CT before surgery. Maximum standardized uptake value（SUVmax）， mean standardized uptake value（SUVmean）and metabolic tumor volume（MTV） of primary lesion were measured， and total lesion glycolysis（TLG） was calculated. Relationship between metabolic parameters and clinicapathological factors was analyzed. Results SUVmax， SUVmean， MTV and TLG of 84 primary lesions were 11.79（5.36，29.48）， 7.11（3.10，19.51）， 14.67（3.22，54.77）cm3 and 96.47（13.18，936.93）g， respectively. SUVmax， SUVmean， MTV and TLG were related to the tumor location， differentiation degree and the maximum diameter（P＜0.05）.T stage were both positively correlation with all metabolic parameters（r=0.318，r=0.281，r=0.390，r=0.416，P＜0.05）. Only the TLG was positively correlation with clinical stage（r=0.355，P=0.001）. Conclusion Metabolic parameters of CRC primary lesion have good correlation with clinicopathological factors， and can reflect partial characteristics of the tumor pathology in a certain extent.