Abstract: Objective To investigate the efficacy of the alleviative treatment of superior vena cava syndrome（SVCS） combined body-γ-knife with chemotherapy. Methods Fifty-five cases of SVCS were treated with γ-knife combined with 1 cycle chemotherapy in the. After the γ-knife treatment，the patients were received 4 to 6 cycles of chemotherapy；the 50％ isodose curve was used as the prescerption isodose curve to wrap PTV，and the 60％ odose curve wrapped more than 90％ GTV；according to the pathological type，the total dose was 45-54 Gy for 10-12 fractions. The symptom relief rate，short-term efficacy and long-term efficacy were observed. Results All of the 55 patients were accomplished treatment according to the plan， all the symptoms of SVCS were relieved during the treatment of γ-knife and median treatment was 6 times.There was no one patient who had not been relieved.The complete remission was achieved in 28 cases （50.9％） within two weeks，the total effective rate of two months was 98.2％（54／55）. There was no one patient with PD. All patients were followed up for 1-31 months. The 1-year survival rate was 72.7％ （40／55）， 2-year survival rate was 43.6％ （24／55）；4 cases of grade 0-1 grade acute radiation pneumonitis （7.2％），3 cases of grade 0-1 grade acute radiation esophagitis （5.4％），9 cases of grade 0-2 bone marrow suppression （16.3％），12 cases of grade 0-2 gastrointestinal reaction （21.8％），4 cases of alopecia （7.2％），and did not appear 3-4 grade adverse reactions. Conclusion γ-knife combined with chemotherapy in the treatment of SVCS has the characteristics of fast response，high efficiency，low recurrence rate，good tolerability and fewer side effects，therefore combined body-γ-knife with chemotherapy as therapeutic strategy is a good method to treat SVCS.