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环状RNA的海绵活性作为肿瘤新型生物标志物可行性的研究进展#br#

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临床肿瘤学杂志 ›› 2018, Vol. 23 ›› Issue (1): 79-83.

#br# 环状RNA的海绵活性作为肿瘤新型生物标志物可行性的研究进展#br#
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1 266000 山东青岛青岛大学附属医院市北院区肿瘤化疗一科

收稿日期:2017-06-12 修回日期:2017-11-02 出版日期:2018-01-30 发布日期:2018-06-28

Progression in the feasibility of cyclic RNA sponge as a novel biomarker for cancer

Department of Tumor Chemotherapy， the Affiliated Hospital of Qingdao University

Received:2017-06-12 Revised:2017-11-02 Online:2018-01-30 Published:2018-06-28

摘要/Abstract

摘要： 目前多项研究表明不同的环状RNA（circRNA）作为特殊的非编码RNA可以通过与特定的miRNA结合发挥海绵活性，并因此抑制miRNA功能，从而影响相关通路的进行，对特定肿瘤的发生发展产生影响。本文通过收集已有实验研究，对内源性circRNA海绵的生物发生、性质和功能进行总结，并对circRNA海绵与人类肿瘤发生发展的影响作一综述。

关键词: 环状RNA（circRNA）, 生物标志物, 综述

Abstract: Resently， many studies have shown that different circRNA can act as a special noncoding RNA which binds to specific miRNAs to play sponge activity. Through this way can inhibit miRNA function， and also affect the relevant pathways and the occurrence and development of specific tumors. The biogenesis， properties and functions of endogenous circulatory sponges were summarized by collecting experimental studies， and the effects of circRNA sponge and human tumor development were reviewed.

Key words: Cyclic RNA（circRNA）, Biomarker, Review

吴银洁, 徐晓彦, 徐飞, 于壮. #br# 环状RNA的海绵活性作为肿瘤新型生物标志物可行性的研究进展#br#

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[J]. 临床肿瘤学杂志, 2018, 23(1): 79-83.

WU Yinjie, XU Xiaoyan, XU Fei, YU Zhuang. . Progression in the feasibility of cyclic RNA sponge as a novel biomarker for cancer[J]. Chinese Clinical Oncology, 2018, 23(1): 79-83.

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