关键词: 胃癌, 复发, 预测, β连环蛋白, 上皮型钙黏蛋白

Abstract: ObjectiveTo investigate the predictive value of βcatenin and Ecadherin in patients with early gastric cancer （stage T12N0） undergoing radical resection. 
MethodsThree hundred and sixtysix patients with early gastric cancer who underwent surgical resection from July 2012 to June 2014 in Suining central hospital were selected. The recurrence of the patients was followed up. Immunohistochemical staining was used to detect the expression of βcatenin and Ecadherin in gastric cancer tissues and their relationship with the clinicopathological characteristics of gastric cancer. Multivariate Logistic regression analysis was used to analyze the independent risk factors for recurrence. 
ResultsA total of 42 patients relapsed during the followup period. There was a significant difference in pathological type， depth of invasion， degree of differentiation， education level and place of residence between recurrent and non recurrent patients （P＜005）. Of the 366 patients， 221 had high expression of βcatenin and high expression of Ecadherin in 150 cases， and the expression of βcatenin and Ecadherin was closely related to the depth of infiltration， degree of differentiation and recurrence （P＜005）. Multivariate Logistic regression analysis showed that invasion depth， abnormal expression of βcatenin and Ecadherin were independent factors for postoperative recurrence of gastric cancer （P＜005）. There was no correlation between the expression of βcatenin and Ecadherin in recurrent gastric cancer （r=-0033， P=0836）. 
ConclusionAbnormal expression of βcatenin and Ecadherin can be used as predictors of postoperative recurrence in early gastric cancer patients， and it is helpful for screening highrisk patients with postoperative recurrence.

Key words: Gastric cancer, Recurrence, Predictor, βcatenin, Ecadherin