关键词: 膀胱癌, 极光激酶B, 基因表达汇编（GEO）, 临床意义, 预后

Abstract: ObjectiveTo investigate the expression of the aurora kinase B （AURKB） gene in the bladder cancer tissues in the NCBI Gene Expression Omnibus （GEO） database and its relationship with the clinicopathological features and prognosis of bladder cancer. 
MethodsGEO datasets were collected and expression profile of AURKB and clinicopathological parameters of bladder cancer tissues were download. The relationship between the AURKB expression and the clinicopathological parameters of bladder cancer （sex， age， invasiveness， T staging， N staging， M staging and disease classification） as well as its relationship with recurrence， metastasis and prognosis were analyzed. The genes regulated by AURKB were analyzed by gene enrichment analysis （GSEA）. 
ResultsThe expression level of AURKB in bladder cancer tissues was 9621±0085， higher than 7691± 0059 of normal bladder tissues， and the difference was statistically significant （P＜005）. The expression of AURKB in bladder cancer was related to sex， invasiveness， T staging， disease classification and progression （P＜005）， not related to age， N staging， M staging and recurrence （P＞005）. The 5year overall survival rate and 5year tumor specific survival rate in the highexpression group of AURKB were 52226％ and 70256％， lower than 70112％ and 90687％ in the lowexpression group， and the difference was statistically significant （P＜005）. GSEA results showed that AURKB highexpression samples enriched the mitosis， E2F transcription factors， G2M checkpoints， MYC signaling pathways， unfolded protein responses and mitotic spindle related genes. 
ConclusionAURKB was highly expressed in bladder cancer and could be considered as a potential marker and target in the diagnosis and treatment of bladder cancer.

Key words: Bladder cancer, Aurora kinase B, Gene Expression Omnibus （GEO）, Clinical significance, Prognosis