Abstract: Astrocyte elevated gene-1（AEG-1） was initially identified and cloned in 2002.It has been proved to be an oncogene. AEG-1 has been reported that it is highly expressed in various types of human cancer， and is positively correlated with tumor differentiation， lymph node metastasis， TNM staging and negatively correlated with prognosis. AEG-1 overexpression activates the PI3K／AKT， NF-κB， MAPK and Wnt signaling pathways in several crucial aspects of the molecular mechanism. AEG-1 plays an important role in the regulation of physiological and pathological process in tumor， including proliferation， invasion， metastasis， formation of the blood vessels and drugresistance. Based on the research findings， AEG-1 has important reference value for diagnosis and prognosis predicting of malignant tumor， and it represents a viable potential target for the prognostic judgement and the therapy of tumor.