Abstract:

Objective To investigate the expression of matrix metalloproteinase-2（MMP-2）， vascular endothelial growth factor （VEGF）， CD105 and Ki-67， the correlations among the 4 indicators， the clinical features and prognosis in small cell lung cancer （SCLC）. Methods From 2004 to 2009， 42 cases of SCLC and 8 cases of normal lung tissues were collected. The expression of MMP-2， VEGF， CD105 and Ki-67 were detected by immunohistochemistry SP method. The correlation among expression of MMP-2， VEGF， CD105 and Ki-67， clinical features and prognosis were analyzed. Results The positive rate of MMP-2， VEGF， CD105 and Ki-67 was 50.0％， 66.7％， 81.0％ and 64.3％ in 42 cases of SCLC tissues， higher than 12.5％， 12.5％， 0 and 0 in normal lung tissues（P＜0.05）. The expression of MMP-2，VEGF and CD105 was correlated with tumor size， lymph node metastasis， distant metastasis and clinical stage（P＜0.05）， while Ki-67 was only correlated with lymph node metastasis（P＜0.05）. The expression of MMP-2 and VEGF was correlated with CD105 and Ki67，and there were significant positive correlations between MMP2 and VEGF（r=0.447，P＜0.05）. Single factor survival analysis showed that tumor size， lymph node metastasis， distant metastasis， clinical stage， and MMP-2， VEGF， CD105 and Ki-67 expression was correlated with the overall survival of SCLC. Conclusion MMP-2， VEGF， CD105 and Ki-67 are prognostic predictors in SCLC.The correlation of MMP-2 and VEGF may participate in angiogenesis and proliferation of SCLC.