Abstract: Objective To evaluate the efficacy and prognostic factors of laryngeal cancer patients treated by surgery combined with radiotherapy. Methods Clinical data of 92 patients with laryngeal cancer treated by surgery and radiotherapy in Anhui provincial hospital were analyzed retrospectively. Log-rank test and Cox multivariate model were used to analyze the prognostic factors. ResultsThe 1-, 3-, 5-, 10-year survival rates were 85.9%, 72.6%, 67.5% and 60.9%, and the 1-, 3-, 5-, 10-year locoregional relapsefree survival were 93.3%, 81.3%, 75.6% and 57.6%. In univariate analysis，the survival was related to patients' age and postoperative lymph node metastasis. In Cox multivariate model，postoperative lymph node metastasis was an independent prognostic factor. Conclusion The postoperative lymph node metastasis is an independent prognostic factor for patients with laryngeal cancer after combined treatment. Postoperative followup and the improvement of locoregional relapse-free survival is important to improve the survival of patients with laryngeal cancer.