Abstract: Objective To investigate the expressions of CD147 and MMP-9 in colorectal cancer，and the correlation of them with cliniopathological characteristics. Methods Expressions of CD147 and MMP-9 in 60 colorectal cancer and 50 adjacent normal tissues were detected by immunohistochemistry，and the relationship of their expressions with clinical characteristics was further analyzed. Results The positive rates of the expressions of CD147 and MMP-9 in 60 cases of colorectal cancer tissues were 86.7％ and 85.0％，higher than 20.0％ and 15.0％ in adjacent normal tissues（P＜0.05）.CD147 and MMP-9 were not related to age, gender, tumor location, differentiation, TNM stage, lymph node metastasis and distant metastasis. CD147 was positively correlated with MMP-9（r=0.470，P＜0.001）. Conclusion MMP-9 and CD147 were over-expressed in colorectal cancer.The role of them in colorectal cancer needs further study.