Objective To investigate the relationship between the gene singlenucleotide polymorphisms（SNP） site of V64I within chemokine receptor 2（CCR-2） and cervical cancer and cervical intraepithelial neoplasia（CIN）. Methods Polymerase chain reaction sequence specific primers（PCR-SSP）， electrophoresis and gene sequencing analysis were applied respectively to detect the CCR2V64I gene SNP in 40 patients with primary cervical cancer，45 patients with CIN and 60 health controls. Results Gene sequencing analysis and electrophoresis showed the same results on the CCR2-V64I gene SNP. The frequencies of G／G， G／A and A／A genotype of V64I polymorphism within CCR2 gene were 27.5％，12.5％ and 60.0％ in cervical cancer， 53.3％，24.4％ and 22.2％ in CIN，and 38.3％， 31.7％ and 42.9％ in control group. There was significant different in the distribution of polymorphism of CCR2-V641 gene polymorphism between cervical cancer and normal control（P＜0.0l），but there was no significant difference between CIN and the normal control（P＞0.05）. Harboring allele A increased the risk of cervical cancer（OR=2.32，95％CI：1.29-4.17）， but did’t increase the risk of CIN（OR=0.62，95％CI：0.35-1.09）. Conclusion CCR2 gene polymorphism exists in cervical cancer and CIN， which correlates with the risk of cervical cancer but not with CIN，indicating that CCR2-V641 gene polymorphism may play an important role in the occurrence and development of cervical cancer.