Abstract: Objective To investigate the expression of EML4-ALK in nonsmall cell lung cancer（NSCLC） and the correlation with clinical pathological features.
Methods The expression of EML4-ALK was detected in 245 cases of NSCLC and 80 cases of adjacent normal tissues using immunohistochemistry and tissue microarray technique. The correlation between the clinicopathological features and the expression of EML4ALK was analyzed. Results The positive rate of EML4-ALK in NSCLC was 7.35％（18／245），while it was 0（0／80）in adjacent normal tissues. EML4-ALK expression was significantly correlated with gender， smoking history， histological type and clinical stage（P＜0.05）. Conclusion EML4-ALK may play an important role in the occurrence and development of NSCLC. It may become a potential target of clinical therapy.