Abstract: Objective To investigate the clinicopathologic characteristics and treatment in patients with brain metastasis from digestive system neoplasms. Methods Nineteen digestive system neoplasms patients with brain metastasis from Jan 1996 to Jan 2012 were retrospectively analyzed. Clinical and image characteristics， treatment and prognosis were analyzed retrospectively. Meanwhile the related literatures were reviewed. Results There were various nervous system symptoms in 17 patients. Enhanced MRI or CT scan showed that there were moderate or significant changes in brain metastasis density and significant edema in tumor peripheral and cystic change in some brain metastasis. The combined therapy of stereotactic radiotherapy，surgery，whole brain radiotherapy， stereotactic aspiration and chemotherapy were applied in these patients. These brain metastasis lesions were controlled at different degrees in all the patients, and nervous system symptoms got improved in 14 patients. The median overall survival of 19 patients was 13.6 months and the 1-year survival rate was 57.9％. Conclusion Clinical manifestations of digestive system neoplasms with brain metastasis were complicated. Local therapy based treatment can be applied.