Abstract: The relationship between tumor and inflammation has been the focus of controversy for a long time. A large number of epidemiological studies have identified a wide variety of tumor associated with chronic inflammation. Chronic inflammation increases the risk of suffering from cancer and promotes the progress of tumor. The body has formed a state of chronic inflammation in the longterm stimulation of the infectious（hepatitis B virus or hepatitis C virus） or noninfectious factors（chronic alcoholism，the accumulation of aflatoxin and metabolic diseases）. It is favourable to promote the occurrence，development and metastasis of hepatocellular carcinoma under this background. But the molecular mechanism between hepatocellular carcinoma and chronic inflammation is not fully clear. This paper reviews the current situation and research progress on the relationship between hepatocellular carcinoma and chronic inflammation in terms of tumor microenvironment，inflammation related signaling pathways and clinical prognosis index of systemic inflammation.