Abstract:

Objective To investigate the expression of deleted in malignant

brain tumor 1（DMBT1） in nasopharyngeal carcinoma， and analyze its

relationship with clinicopathological characteristics. Methods The DMBT1 protein expression in 69 cases of nasopharyngeal carcinoma tissues and 36 cases of normal nasopharyngeal tissue adjacent to carcinoma were determined by immunohistochemistry. The relationship between DMBT1 expression and clinicopathological characteristics and prognosis were analyzed. Results The positive rate of DMBT1 protein expression in nasopharyngeal carcinoma tissues was 33.3％（23／69）， significantly lower than 75.0％（27／36）in adjacent normal nasopharyngeal tissues（P＜0.05）. The level of DMBT1 protein expression was correlated with T stage， lymph node metastasis，clinical stage and histological grade（P＜0.05）. The median overall survival time in patients with DMBT1 positive and negative expression was 60.0 months and 47.0 months respectively（P＜0.05）. Cox regression analysis showed that DMBT1 negative expression was an independent risk factor for prognosis of patients with nasopharyngeal carcinoma（P＜0.05）. Conclusion DMBT1 plays an important role in the development of nasopharyngeal carcinoma， and can be used as a prognostic indicator of patients with nasopharyngeal carcinoma.