Abstract:

MicroRNAs are a kind of small noncoding RNA molecules in eukaryotes， which regulate target gene expression in the posttranscription level. MicroRNAs play a significant role in development of malignant tumors. Epithelial to mesenchymal transformation occurred in cancer progression， which gets rid of the connection of the cells and acquires invasiveness and metastatic capability. This paper reviews the dysregulation of some MicroRNAs， which have diagnostic value of invasion， metastasis and prognosis of esophageal squamous carcinoma. Therefore， MicroRNAs will serve as new biological targets for the early diagnosis and gene therapy of esophageal squamous carcinoma.