Abstract: Objective To evaluate the clinical effect of simultaneous bilateral laparoscopic inguinal lymphadenectomy for penile cancer. Methods From April 2012 to August 2014， 14 patients with squamous cell carcinoma of the penis receiving simultaneous bilateral laparoscopic inguinal lymphadenectomy were enrolled. The perioperative results and followup data were analyzed. Results The operations were successfully performed in all patients. The mean operative time was 112 min. The mean blood loss was 47 ml. The mean hospital duration was 10 d. The mean number of lymph nodes was 9.1. One patient had fever and there was seroma in his right limb after operation but he got recover soon. The other patients had no complications. Followup ranged from 2 to 48 months， there was no evidence of recurrence and metastasis. Conclusion Simultaneous bilateral laparoscopic inguinal lymphadenectomy is a safe and effective technique. It leads to less intraoperative blood loss， less hospitalization duration， less postoperative complications and quick postoperative recovery.