Abstract: Objective To detect the expressions of β-catenin， RIPK4， CDK8 and assess the relationship between the expressions of above proteins in mantle cell lymphoma（MCL） with their clinicopathological characteristics and prognosis. Methods Strept AvidinBiotin Complex immunohistochemistry was used to detect the expression of β-catenin， RIPK4 and CDK8 in 30 samples of MCL and 16 samples of lymphadenitis. All MCL patients were followed-up. The expressions of β-catenin， RIPK4 and CDK8 in MCL and lymphadentis tissues were compared. The correlation of above proteins and the relationship between the expression of them in MCL with their clinicopathological characteristics and prognosis were analyzed. Results Positive expression rates of β-catenin， RIPK4 and CDK8 in MCL tissues were 55.3％, 63.3％ and 60.0％， which were higher than those of lymphadenitis samples（P＜0.05）. There was a positive correlation among the expression of βcatenin， RIPK4 and CDK8（r=0.600，r=0.675，r=0.367，P＜0.05）. The expression of β-catenin， RIPK4 and CDK8 had no significant correlation with the gender， age， MIPI score， the level of β2-microglobulin， B symptoms and clinical stage（P＞0.05）. The median overall survival （OS） of MCL patients was 21 months. MIPI score of high risk group， the positive expression of CDK8 were independent predictors of OS. Conclusion There were high expression rate of β-catenin， RIPK4 and CDK8 proteins in MCL. There was a positive correlation among the expression of β-catenin， RIPK4 and CDK8. The positive expression of CDK8 indicated a poor prognosis of MCL.