Chinese Clinical Oncology

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CTLA-4 T cells immune targeted therapy based and status of transformation research in non-small cell lung cancer

YU Zongyang， MO Xiangyang， OUYANG Xuenong.   

  1. Department of Medical Oncology， Fuzhou General Hospital of Nanjing Military Command， Fuzhou 350025，China
  • Received:2014-09-22 Revised:2014-11-27 Online:2015-04-30 Published:2015-04-30

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Abstract: Cytotoxic T lymphocyte associated（CTLA-4） is a kind of leukocyte differentiation antigens， it participates in the negative regulation of immune response. As the treatment of non-small cell lung cancer （NSCLC） model by the driver gene targeted therapy to immune targeted therapy，CDLA-4 has become a new research hotspot. This article combing CDLA-4 research of NSCLC in recent years and reviews the connecting with the related basic and clinical research progress.

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